The latest research on the effects of mitogen-activated protein kinase 1/2 and extracellular signal-regulated kinase 1/2 has shown that 6-ME can inhibit tumor angiogenesis by targeting the phosphorylation of mitogen-activated protein kinase 1/2 and its downstream substrate extracellular signal-regulated kinase 1⁄2. The gene discussed is MAPK1; the disease is neoplasm.