In order to detect whether the angiogenesis inhibitory effect of TTF1 is related to the expression of VEGF, KDR, bFGF, COX-2 and HIF-1α, the protein levels of these factors in hepg-2-induced mouse tumor were measured The expression of VEGF, KDR, bFGF, COX-2 and HIF-1α was decreased by TTF1 at different concentrations (5 μmol kg−1, 10 μmol kg−1 and 20 μmol kg−1), respectively White matter level to achieve anti angiogenesis effect (Liu et al., 2011a). This evidence concerns the gene HIF1A and neoplasm.