Interestingly, unlike observations in Commd1-deficient embryos (Van De Sluis et al., 2007), observations from tumor cell lines (Muller et al., 2009; Van De Sluis et al., 2010), myocardial infarction mouse model (Li et al., 2020) and our cerebral infarction rats model with reduced expression of COMMD1 did not show increased protein levels of HIF-1α. Here, HIF1A is linked to neoplasm.