As a 2-year follow-up analysis indicated, the same five patients reported a 57% and 63% increase in their OFF-medication motor and everyday life sub-scores (Unified Parkinson’s Disease Rating Scale) behaviors after 2 years of therapy, the impact of GDNF treatment tended to have long-lasting effects in these persons (Patel et al., 2005). This evidence concerns the gene GDNF and Parkinson disease.