The neuropathology of AD is characterized by the accumulation of amyloid β (Aβ) in the form of amyloid plaques and congophilic amyloid angiopathy, as well as the accumulation of abnormally phosphorylated tau, in the form of NFTs (Nelson et al., 2012; Long and Holtzman, 2019). Here, MAPT is linked to Alzheimer disease.