Also, it had been shown that both the Aβo impairment of LTP in vitro and Aβo mediated toxicity in an amyloid model of AD could be blocked by an anti-PrP monoclonal antibody (mAb) 6D11 in vivo (Laurén et al., 2009; Chung et al., 2010). The gene discussed is PRNP; the disease is Alzheimer disease.