sTNFR2 has previously been found to be highly correlated with CSF t-tau, p-tau, and neuron-specific enolase in MCI-AD (Pillai et al., 2019b), and a similar profile with TNFRSF1B activation was noted in a parallel brain transcriptome analysis (Pillai et al., 2019b). The gene discussed is MAPT; the disease is Alzheimer disease.