MAPT and Alzheimer disease: These results are reflected in our study, which demonstrated that a significant interaction between rs976881 and CSF sTNFR2 modulated favorable outcomes in three measures related to AD severity: CSF biomarkers of neurodegeneration and tau (CSF p-tau and t-tau), MRI measures (hippocampal and whole brain volumes), and cognitive measures (Digit Span Forward score and CDR-SB score).