The TNFRSF1B gene (also known as TNFR2) and its variants have previously been linked with inflammatory responses, inflammatory disease outcomes, and rate of cancer progression (Fairfax et al., 2011; Steenholdt et al., 2012; Singhal et al., 2016), but the role of these gene variants in AD has yet to be elucidated. The gene discussed is TNFRSF1B; the disease is Alzheimer disease.