While many studies have highlighted the direct association of the pathological pool of α-Syn with mitochondrial dysfunction (Banerjee et al., 2010; Wilkaniec et al., 2013; Ganjam et al., 2019), it is largely unknown whether impairment in parkin-dependent mitophagy might have an important role in PD, especially since it has been demonstrated that parkin knockout mice did not display a neurodegenerative phenotype (Pickrell and Youle, 2015). The gene discussed is PRKN; the disease is Parkinson disease.