Emerging studies find HMGB1 release contributes to induction of TLR and RAGE neuroimmune receptors as well as other neuroimmune genes, contributing to neurodegeneration in brain diseases, including AD and AUD (Crews et al., 2013; Vetreno et al., 2013, 2018; Heneka et al., 2015; Paudel et al., 2020). Here, AGER is linked to brain disorder.