IL6 and Behcet disease: Knijff et al. (2007) found significantly altered pro-inflammatory responses in monocytes from BD patients compared to controls after lipopolysaccharide (LPS) stimulation, including increased IL-6. Conversely, when monocyte-derived macrophages from SCZ patients were stimulated with LPS or IL-4, no differences in functional responses at the gene-expression level were found, indicating a normal response to stimulation in SCZ macrophages (Ormel et al., 2017).