MAPT and Alzheimer disease: In addition, no significant correlation was calculated between altered nodal properties and CSF biomarkers in HC and MCI patients, and the betweenness centrality in the right parahippocampal gyrus was negatively correlated with CSF t-tau (r =-0.373, P = 0.03) (Figure 4A) and p-tau (r = -0.386, P = 0.024) (Figure 4B) concentration in AD patients.