Given that AD is associated with autophagic-endosomal-lysosomal dysfunction (Nixon et al., 2008), we speculate that INPP5E and OCRL, highly expressed in the brain and critical in autophagosome-lysosome fusion (De Leo et al., 2016; Hasegawa et al., 2016), might be involved in dysregulation of autophagy in AD brains. This evidence concerns the gene INPP5E and Alzheimer disease.