MAPT and Alzheimer disease: Such early changes in tau phosphorylation were consistent with another study that utilized the CCI model in a triple-transgenic mouse (3×Tg-AD), where an increase in phosphorylated-tau expression in the fimbria and the CA1 region of the hippocampus, along with the deposition of amyloid-β plaques within 1 week of the injury were reported (Tran et al., 2011a).