MAPT and Alzheimer disease: Distinctive but overlapping features of TBI and AD, apart from the associated cognitive deficits, are the deposition of fragments of the β-amyloid peptide to form plaques, and aggregation of hyperphosphorylated forms of the microtubule-associated protein tau to form intracellular neurofibrillary tangles (NFTs) (Tran et al., 2011a, b; Johnson et al., 2012; Magnoni et al., 2012).