The present study aimed to examine differences between a 44-year-old woman high-grade U87 MG cell line32 xenograft (U87) and a 13-year-old boy high-grade PBT24 cell line33 xenograft (PBT24) studied in vivo using the CAM model; to examine these tumors’ response to treatment with NaDCA or magnesium dichloroacetate (MgDCA) preparations as well as their effect on proliferating cell nuclear antigen (PCNA) and enhancer of zeste homolog 2 (EZH2) expression in tumor cells. Here, EZH2 is linked to neoplasm.