PDK1 and central nervous system cancer: The pediatric U373 and U373vIII cell line GB tumors, formed by being intracranially injected into female athymic nude mice, are sensitive to NaDCA treatment, and it decreased the pyruvate dehydrogenase kinase 1 expression in the tumors.16 NaDCA significantly inhibited several pediatric high-grade gliomas cells’ viability.17