Specifically, mannose-binding lectin (MBL)-deleted (Mbl−/−) mice have mild tumor pathogenesis, while recombinant C3a (rC3a) increases pancreatic tumor volume, suggesting that glycan of fungal cell wall-MBL-complement cascade pathway plays an important role in pancreatic diseases (Fig. 4) [127]. The gene discussed is MBL2; the disease is neoplasm.