On the cellular and molecular side, using in vivo models of airway inflammation and in vitro culture of human bronchial epithelial (HBE) cells exposed to PM2.5 and resveratrol (SIRT1 activator), SIRT1 expression was decreased in HBE cells and lung tissues after PM2.5 exposure, suggesting that SIRT1 is involved in the pathogenesis of PM-induced airway inflammation [29]. The gene discussed is SIRT1; the disease is inflammatory response.