Moreover, the combination of IR, as assessed by HOMA-IR, and systemic inflammation, as assessed by CRP, was associated with all-cause and CVD mortality in community-dwelling older individuals from the InCHIANTI Study [38], whereas Lee et al. showed that CRP was an independent predictor of all-cause and cancer-related, but not CVD mortality, irrespective of HOMA-IR [39]. The gene discussed is CRP; the disease is cancer.