ABCG2 and gout: 2010; Xu et al. 2017). ABCG2, a half-transporter protein with an ATP-binding cassette, has also been genetically linked to serum uric acid (SUA) level, HUA and gout (Wright et al. 2010; Xu et al. 2017). ABCG2 mediates renal and/or extra-renal urate excretion as a high-capacity exporter and is abundantly expressed in the proximal tubule cells, at the apical membrane, and in hepatocytes (Woodward et al. 2009; Hosomi et al. 2012).