SHBG and obesity due to melanocortin 4 receptor deficiency: In the combined cohort, serum SHBG levels were not significantly different between men with and without obesity, whereas SHBG levels were lower in women who were obese (β: −0.083, 95% CI: −0.212; 0.046; Figure 2A and β: −0.183, 95% CI: −0.361; −0.005; Figure 2B, respectively; adjusted for study population).