Immunohistochemistry analyses of tumor xenografts showed high cell proliferation (ki67 marker) in both MCF7-POU1F1 and MCF7-POU1F1-shLDHA groups with respect to MCF7-injected group, but ki67 staining was reduced in MCF7-POU1F1-shLDHA as compared to the MCF7-POU1F1 injected mice (Fig. 5D). This evidence concerns the gene MKI67 and neoplasm.