Tumor volume in MCF7-injected mice was negligible at day 15, but a continuous growth of tumor volume in both the MCF7-POU1F1 and the MCF7-POU1F1-shLDHA groups was observed during the study, being significatively higher at 9, 12, and 15 days in MCF7-POU1F1 mice comparing to LDHA knocked-down mice (Fig. 5B). The gene discussed is LDHA; the disease is neoplasm.