TG-101348 is a weak inducer of apoptosis (IC50; 4.95 μM), albeit its potent inhibition against JAK2 (IC50, 3 nM)37 than TG02 (IC50, 19 nM for JAK2), suggesting neither FLT3 nor JAK2 contribute substantially to CLL survival. The gene discussed is JAK2; the disease is B-cell chronic lymphocytic leukemia.