When CLL cells were incubated with TG02 for 4 and 24 h, there was a clear decrease in the phosphorylation of RNA pol II at the Ser2 sites of the C-terminal domain (CTD) (Fig. 2A, and quantitated in Fig. 2B), consistent with the inhibition of CDK9. This evidence concerns the gene CDK9 and B-cell chronic lymphocytic leukemia.