CD4 and cancer: Moreover, dendritic cells (resting), M0 and M1 macrophages, mast cells (activated), memory B cells, CD4+ naive T cells, and CD4+ memory T cells (activated) were significantly enriched in cancer tissues relative to normal tissues, while mast cells (resting), M2 macrophages, naive B cells, CD8+ T cells, gamma and delta T cells, plasma cells, Tregs, and monocytes were significantly reduced in cancer tissues (Figure 2A, 2B, 2D).