CD274 and cancer: Besides, the substrate proteins were found to participate in some intriguing pathways, such as EGFR tyrosine kinase inhibitor resistance, Fc epsilon RI signaling pathway, platinum drug resistance, human T-cell leukemia virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, and Fc gamma R-mediated phagocytosis (Figure 6C).