TACC3 and cervical cancer: TACC3-mediated induction of EMT in human cervical cancer cells could be explained as follows: overexpressed TACC3 may increase the expression of Snail and Slug, as well as the transcriptional activity of β-catenin, by (1) increasing the phosphorylation of AKT and ERK1/2 and/or (2) decreasing GSK3β activation, a downstream target of the PI3K/AKT signaling pathway.