Genetic information for the Top 20 cumulative mutations were TP53, TTN, MUC16, CTNNB1, PCLO, HMCN1, OBSCN, ALB, LRP1, MUC4, RYR2, SPTA1, SYNE1, AHNAK2, ARID1A, CSMD3, DNAH2, DNAH5, PTPRQ and WDR87. C>T was the most common single nucleotide mutation (SNV) in HCC (Figure 1B). The gene discussed is SYNE1; the disease is hepatocellular carcinoma.