Other component genes of the TMB-IF panel included DCN, DSE, EVI2A, FPR3, P2RY13, GEM, PMP22, SLC9A9 and DOCK8. DCN has been reported to be associated with DNA methylation and hydroxy-methylation in HBV-related HCC [39], and DSE dysregulation may contributed to the malignant behavior of HCC cells through suppression of CCL5 signaling [40]. This evidence concerns the gene CCL5 and hepatocellular carcinoma.