AKT1 and gastric cancer: Results indicated that activation of the PI3K/AKT pathway by 740Y-P or SC79 in SGC7901/DDP cells with miR-95-3p knockdown induced an increase in MDR1 and ABCC1 expression (Figure 10D), which further validated that miR-95-3p contributes to the development of DDP resistance in gastric cancer.