More importantly, Tsunemi’s laboratory revealed that PGC-1α rescues Huntington’s disease proteotoxicity by promoting the transactivation of TFEB, a master regulator of the autophagy-lysosome pathway [27], suggesting that PGC-1α may activate autophagy through a TFEB-dependent mechanism [28, 29]. The gene discussed is PPARGC1A; the disease is juvenile Huntington disease.