With respect to differentially expressed lncRNA-targeted mRNAs (colocated and coexpressed mRNAs), up- and downregulated lncRNA-targeted mRNAs (coexpressed) were related to such pathways as biotin metabolism, type II diabetes mellitus, amino sugar and nucleotide sugar metabolism, and the GnRH signaling pathway (Figure 4C–4D). This evidence concerns the gene GNRH1 and type 2 diabetes mellitus.