In contrast, among the patients who also had available data on baseline central Ki67 assessment, Ki67 ≥ 12% (more than the median value) was independently prognostic for worse OS [adjusted HR (HRadj) = 2.72, 95% CI 1.19-6.21, P = 0.02] when adjusted for tumor size, nodal status, age, baseline TK1 and stratified for ER status. The gene discussed is ESR1; the disease is neoplasm.