To catalogue the ability of TERT to regulate the miR500 cluster as a noncanonical function and its relevance in cancer invasion, we studied whether the absence of telomerase activity affects this activity and the invasiveness of tumour cells in vivo using two different approaches: a genetic approach using a DN‐TERT, and a pharmacological approach inhibiting either the TERT or TERC subunits. Here, TERC is linked to cancer.