Although both chemicals were able to inhibit telomerase activity (Fig. S5A), only BIBR 1532 decreased both the expression of miR500A (Fig. 5E) and tumour invasiveness in vivo (Fig. 5F), indicating that the effect of BIBR 1532 was not due to its action on telomerase activity but due to its ability to block TERT transcriptional activity. Here, TERT is linked to neoplasm.