An effect of Arg/Lys dietary suplementantion on anxiety states was also studied in humans, with a week long treatment with aminoacids (at dose 2.6 g/day) decreasing stress-induced anxiety, reducing concentrations of salivary chromogranin-A (a marker of adrenal sympathetic activity) and cortisol in Japanese male participants [57]. The gene discussed is CHGA; the disease is Anxiety.