Interestingly, a previous intra-BNST injections of CP376395, a CRF type 1 receptor antagonist (CRF1), or AP-7, an NMDA (N-methyl-d-aspartate) attenuated the anxiety promoting effects of administered NO-donor, suggesting that CRF1 and glutamatergic signaling differentially affect NO-induced aversive behavior in the mouse BNST [60]. This evidence concerns the gene CRHR1 and Anxiety.