CDH1 and melanoma: At present, many studies have confirmed that curcumin can regulate EMT pathway, for example, curcumin inhibited cancer cell invasion via downregulating MMPs and uPA [31]; curcumin exhibits antimetastatic properties of melanoma cells by regulating integrin receptors, collagenase activity, and expression of nonmetastatic gene 23 (Nm23), and E-cadherin [32].