KEGG pathway analyses revealed differential expression in curcumin-treated LGR5(+) cells involved in ‘Pathways in cancer,’ ‘PI3K-Akt signaling pathway,’ ‘MAPK signaling pathway,’ ‘Wnt signaling pathway,’ ‘NF-kappa B signaling pathway,’ ‘ECM-receptor interaction,’ and ‘Lysosome’ (Data not shown). Here, LGR5 is linked to cancer.