Next, the RNA-Seq data showed that curcumin decreased the expression of GP1BB, COL9A3, COMP, AGRN, ITGB4, LAMA5, COL2A1, ITGB6, ITGA1, and TNC in the ECM–receptor interaction pathway, which is also associated with shorter survival of CRC patients. This evidence concerns the gene COMP and colorectal carcinoma.