Next, the RNA-Seq data showed that curcumin decreased the expression of GP1BB, COL9A3, COMP, AGRN, ITGB4, LAMA5, COL2A1, ITGB6, ITGA1, and TNC in the ECM–receptor interaction pathway, which is also associated with shorter survival of CRC patients. The gene discussed is COL2A1; the disease is colorectal carcinoma.