The over-secretion of growth hormone (GH) characterizes acromegaly, a rare chronic disease with a worldwide prevalence of 40–130 per million, most commonly due to a pituitary tumor, and associated with multiple comorbidities, such as diabetes mellitus (DM), sleep apnea, arthropathy, cardiovascular system disorders, and cancer [1]. This evidence concerns the gene GH1 and pituitary tumor.