Herein, we first investigated the expression patterns of GAS2 family genes, including GAS2, GAS2L1, GAS2L2, and GAS2L3, in the glioma tissues, and explored the potential correlation between the expression level of GAS2 family genes and the clinical prognosis of glioma cases within TCGA or CGGA databases. The gene discussed is GAS2L1; the disease is central nervous system cancer.