Herein, we first investigated the expression patterns of GAS2 family genes, including GAS2, GAS2L1, GAS2L2, and GAS2L3, in the glioma tissues, and explored the potential correlation between the expression level of GAS2 family genes and the clinical prognosis of glioma cases within TCGA or CGGA databases. Here, GAS2L2 is linked to central nervous system cancer.