GAS2 and central nervous system cancer: Even though we failed to observe an obvious DNA methylation status of GAS2, GAS2L1, and GAS2L2 (data not shown) in the CGGA Methyl_159 dataset, a reduced DNA methylation level of GAS2L3 was negatively correlated with the glioma WHO classification (Figure 3A) and led to a poor prognosis of primary glioma (Figure 3B, p < 0.0001).