For example, in a VaD mouse model, Yui et al. reported a cerebral ischemia–induced contextual memory deficit, and both activated CaMKII (including α and β isoforms) and the total CaMKIIα and CaMKIIβ expressions were significantly decreased in the hippocampal CA1 region at 12 days in bilateral common carotid artery occlusion (BCCAO) mice [133]. Here, CAMK2G is linked to brain ischemia.