Additionally, past studies mainly focus on CaMKII holoenzyme and CaMKIIα (the most abundant CaMKII isoform in the brain) in neurons, but there is sparse information on CaMKII in other cell types within the neurovascular unit (such as endothelial cells, pericytes, smooth muscle cells, astrocytes, microglia, and extracellular matrix) and the functions of other CaMKII isoforms in ischemic stroke are largely unknown. This evidence concerns the gene CAMK2G and ischemic stroke.