Although we did not find any reports on CaMKII per se in other cerebrovascular diseases, such as intracranial stenosis, aneurysms, vascular malformations, etc., these diseases are common causes of ischemic or hemorrhagic stroke, for example, intracranial stenosis is the narrowing of an artery in the brain, which often leads to ischemic stroke. The gene discussed is CAMK2G; the disease is ischemic stroke.