The same applies to somatic mutations in JAK2 that have been reported in a wide spectrum of diseases, such as acute lymphoblastic leukemia in pediatric patients with trisomy 21 [39], acute myeloid leukemia (AML) in adulthood [40], and myelodysplastic/myeloproliferative neoplasms (MDS/MPN) with ring sideroblasts and thrombocytosis (MPN/MDS-RS-T) [81]. Here, JAK2 is linked to myeloproliferative disorder.