APP and Dravet syndrome: Of note, the 5xFAD mouse model of EOAD used here does not provide a good model for DS in terms of construct validity, due to several reasons: (a) the model is based on APP and PSEN1 mutations rather than on APP triplication, (b) the 5xFAD model lacks triplication of non-APP Hsa21 genes, and (c) the mutations in PSEN1, which is not characteristic of DS, may result in a confounding effect.