This agrees with our findings, in that shRNA-mediated knockdown of PSMD1 or PSMD3 in CML cells reduced NF-κB protein expression and transcriptional activity (Fig. 7), suggesting that PSMD1 and PSMD3 regulate NF-κB protein expression, rather than targeting the canonical signaling pathway. The gene discussed is PSMD3; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.