NFKB1 and chronic myelogenous leukemia, BCR-ABL1 positive: This agrees with our findings, in that shRNA-mediated knockdown of PSMD1 or PSMD3 in CML cells reduced NF-κB protein expression and transcriptional activity (Fig. 7), suggesting that PSMD1 and PSMD3 regulate NF-κB protein expression, rather than targeting the canonical signaling pathway.