The expression of the fifteen mRNAs was validated by GEPIA online software, and the expression levels of ALDOA, CFB, GAPDH, LDHA, MESDC2, PPIA, TMSB10, TUBA1B, and UBE2F were higher in stage II patients than in stage I patients with lung adenocarcinoma and lung squamous cell carcinoma, which was consistent with our previous results in the gene sets. The gene discussed is MESD; the disease is lung adenocarcinoma.