Although there are no studies on eight of the mRNAs (TUBA1B, UBC, PPIA, PML, MESDC2, CFB, UBE2F, TMSB10) in prognosis of NSCLC, our experimental results shown these 15 mRNAs are involved in the progression of NSCLC, these experimental results provide evidence for the roles of these mRNAs in NSCLC and identify them as biomarkers. This evidence concerns the gene PPIA and non-small cell lung carcinoma.