Whereas results of one study indicated residues downstream from Asp270 (analogous to RSV IN residue Thr270) in HIV-1 were critical to support the infection of a single-round reporter virus28, the results of a separate study revealed that a virus terminating at Arg269 (analogous to RSV IN residue Ile269) supported efficient HIV-1 replication29. The gene discussed is CD44; the disease is infection.