Re-expression of seven different EZH2 variants, (Supplementary Fig. 3b) found in the AML-CG-1999 and AML-CG-2008 studies, could only partially rescue global H3K27me3 levels, indicating a LOF phenotype, while the re-expressed wildtype protein was able to restore complete activity (Fig. 3e). The gene discussed is EZH2; the disease is acute myeloid leukemia.