We furthermore identified upregulation of the direct EZH2 target genes CNN3 and AKAP13, that are involved in chemotherapy resistance in colon cancer and breast cancer, respectively60,61, and the genes MYO5A, AKT3 and SPECC1, which are implicated in the evasion of apoptosis62–64. This evidence concerns the gene CNN3 and malignant colon neoplasm.