Among PRAD IC genes known to be involved in the KEGG prostate cancer disease pathway (https://www.kegg.jp/kegg-bin/show_pathway?hsa05215), BAD, CREB1, CREB3L4, CREBBP, EP300, and TCF7L1 genes are all involved also in the metabolic pathway known to regulate cell apoptosis and proliferation, while GSTP1 regulates the carcinogenesis of PRAD and it is also involved in the metabolic process; instead, SPINT1 and ZEB1 regulate gene expression and they also play an important role in the PRAD pathway by promoting cellular migration and invasion. Here, CREB3L4 is linked to Familial prostate cancer.