TARDBP and amyotrophic lateral sclerosis: One of the features of ALS and FTLD pathology is phosphorylation of Ser residues within the C-terminal part of the TDP-43 LCD, with the consensus pathological phosphorylation sites at Ser403, Ser404, and Ser409/410, and additional disease-specific phosphorylation sites at Ser379 and Ser3693,38.