For example, a robust IFN-response in HCC827 cells and antigen presentation in tolerant xenograft tumor cells are consistent with clinical evidence of EGFR-TKIs increasing IFNγ-induced MHC class-I presentation, which may lead to enhanced recognition and lysis of tumor cells by CD8+ cytotoxic T lymphocytes70. The gene discussed is CD8A; the disease is neoplasm.