ADAR and cancer: Furthermore, dot blot analysis of DRIP products using a telomeric repeat probe revealed that ADAR1 depletion resulted in the formation of telomeric repeat RNA:DNA hybrids specifically in non-ALT cancer cell lines, for example, HeLa (Fig. 3c), HEK293T, and HCT116 (Fig. 9b and Supplementary Fig. 9).