IQSEC1 and neoplasm: In the few mice presenting macrometastases in IQSEC1-depleted cells, these were limited to prostate proximal lymph nodes (with the exception of a singular diaphragm-located tumour) (Fig. 7h), and showed no difference in proliferation or apoptosis to controls, confirming a bona fide effect on movement (Fig. 7i, j).