TTR and central nervous system cancer: Furthermore, univariate and multivariate analyses revealed that in addition to WHO grade and age, the combination of ANXA2 and GPC1 (ANXA2/GPC1) was an independent prognostic factor for TTR (P < 0.001, HR = 3.575, respectively) and OS (P = 0.001, HR = 2.174, respectively) in glioma patients (Table 2).