Using this approach, we identified previously nominated AD risk genes MS4A4A12, MS4A6A12, SPI112, as well as novel candidate causal genes AP4E1, AP4M1, PILRA, RABEP1, SPPL2A, TP53INP1, ZKSCAN1, and ZYX in twelve loci. The gene discussed is RABEP1; the disease is Alzheimer disease.