Conversely, in the ZYX (previously EPHA1) locus, we observed stronger chromatin interactions with a ZYX promoter in macrophages (mean interaction score 3.3 and 7.0 in monocytes and macrophages, respectively) and different eQTL signal profiles between monocytes and macrophages, suggesting that the AD risk regulome is different in these two cell types albeit pointing to the same candidate causal gene (Supplementary Figure 1). Here, EPHA1 is linked to Alzheimer disease.