PILRA and early-onset autosomal dominant Alzheimer disease: We identified a missense variant (rs1859788-G) in PILRA that is in high LD with the tagging variant (R2 = 0.86, Alzheimer’s Disease Genetics Consortium case-control cohort (ADGC) reference panel was used to compute LD as described previously)12 and was previously shown to alter the ligand binding affinity of PILRA31.