These analyses revealed specific active chromatin regions in monocytes, whose activity is causally associated with expression of their target genes, which in turn is causally associated with AD risk, including BIN1, GPR141, MS4A4A, MS4A6A, RABEP1, SPI1, TP53INP1, and ZYX (Fig. 3b, Supplementary Data 4). The gene discussed is BIN1; the disease is Alzheimer disease.