These analyses revealed specific active chromatin regions in monocytes, whose activity is causally associated with expression of their target genes, which in turn is causally associated with AD risk, including BIN1, GPR141, MS4A4A, MS4A6A, RABEP1, SPI1, TP53INP1, and ZYX (Fig. 3b, Supplementary Data 4). This evidence concerns the gene GPR141 and Alzheimer disease.