Furthermore, coding variants that increase risk for AD have been identified in SORL14,68, a member of the vacuolar protein sorting 10 (VPS10)- domain-containing receptor family and the low density lipoprotein receptor (LDLR) family of APOE receptors that is expressed primarily in microglia in the brain15 and plays important roles in the endolysosomal system and APP processing66. Here, APP is linked to Alzheimer disease.