In our study, we discovered a super-enhancer at about 15 kb upstream of EphA2 that is present in various tumor cells, including A549, HeLa, MCF-7, HCT-116, Panc-1, T24, MKN45, BT16, A498 and K562 cells from super-enhancer databases. The gene discussed is EPHA2; the disease is neoplasm.