SQSTM1 and hepatocellular carcinoma: A study in 2019 indicated that there was a lower miR-223 expression in HCC cells compared with normal liver cells, while overexpression of miR-223 directly caused the low expression of FOXO3a, which inhibited doxorubicin-induced autophagy levels by decreasing the LC3-II/LC3-I ratio while increasing p62 expression and caused doxorubicin resistance129.