Thus, these results confirm that PRDX1 is required for the resistance of CRC cells to etoposide-induced apoptosis: although DNA damage caused by etoposide increases the transcription of NOXA mRNA, CRC cells induce the neddylation pathway to accelerate NOXA degradation, thereby minimizing its apoptosis-inducing effect. This evidence concerns the gene PMAIP1 and colorectal carcinoma.