PMAIP1 and colorectal carcinoma: When assessing correlation between the level of PRDX1 and the turnover rate of NOXA in the 5 CRC cell lines, we found a negative correlation between the PRDX1 protein level and the NOXA protein half-life: the higher the protein level of PRDX1 was, the lower the NOXA protein half-life (Fig. 3B).