When EHF-SF was overexpressed in MDA-MB-231 cells, the cell morphology was altered from spindle-like to cobblestone-like shapes, a change that was accompanied by repression of ZEB1 and ETS1 as well as in vitro cell migration and anti-cancer drug resistance (Figs. 4F, G, H, and S3H). This evidence concerns the gene ETS1 and cancer.